The limited availability of freshwater in renewable energy-rich areas has led to the exploration of seawater electrolysis for green hydrogen production. However, the complex composition of seawater presents substantial challenges such as electrode corrosion and electrolyzer failure, calling into question the technological and economic feasibility of direct seawater splitting. Despite many efforts, a comprehensive overview and analysis of seawater electrolysis, including electrochemical fundamentals, materials, and technologies of recent breakthroughs, is still lacking. In this review, we systematically examine recent advances in electrocatalytic seawater splitting and critically evaluate the obstacles to optimizing water supply, materials, and devices for stable hydrogen production from seawater. We demonstrate that robust materials and innovative technologies, especially selective catalysts and high-performance devices, are critical for efficient seawater electrolysis. We then outline and discuss future directions that could advance the techno-economic feasibility of this emerging field, providing a roadmap toward the design and commercialization of materials that can enable efficient, cost-effective, and sustainable seawater electrolysis.