Neuronal γ-secretase regulates synaptic functions via cholesterol homeostasis

Neuron. 2023 Oct 18;111(20):3133-3135. doi: 10.1016/j.neuron.2023.09.021.

Abstract

In this issue of Neuron, Essayan-Perez and Südhof1 demonstrate roles for γ-secretase in the regulation of synaptic functions in human neurons. Chronic attenuation of γ-secretase activity increases synapse formation but decreases neurotransmission (i.e., the probability of presynaptic release), likely due to impairment of cholesterol metabolism.

Publication types

  • Comment

MeSH terms

  • Amyloid Precursor Protein Secretases* / metabolism
  • Cholesterol / metabolism
  • Homeostasis
  • Humans
  • Neurons* / metabolism
  • Synapses / metabolism
  • Synaptic Transmission / physiology

Substances

  • Amyloid Precursor Protein Secretases
  • Cholesterol