Society for Maternal-Fetal Medicine Consult Series #68: Sickle cell disease in pregnancy

Am J Obstet Gynecol. 2024 Feb;230(2):B17-B40. doi: 10.1016/j.ajog.2023.10.031. Epub 2023 Oct 21.

Abstract

Pregnant individuals with sickle cell disease have an increased risk of maternal and perinatal morbidity and mortality. However, prepregnancy counseling and multidisciplinary care can lead to favorable maternal and neonatal outcomes. In this consult series, we summarize what is known about sickle cell disease and provide guidance for sickle cell disease management during pregnancy. The following are Society for Maternal-Fetal Medicine recommendations.

Keywords: antenatal surveillance; disparities; fetal growth restriction; hemoglobinopathy; hydroxyurea; maternal morbidity; maternal mortality; pain management; perinatal outcomes; prepregnancy counseling; transfusion; vaso-occlusive crisis.

MeSH terms

  • Anemia, Sickle Cell* / therapy
  • Female
  • Humans
  • Infant, Newborn
  • Perinatology
  • Pregnancy
  • Pregnancy Complications, Hematologic* / diagnosis
  • Pregnancy Complications, Hematologic* / therapy