High Rates of Seroprotection and Seroconversion to Vaccine-Preventable Infections in the Early Post-Autologous Stem Cell Transplant Period

Victoria G Hall; Natalie R Saunders; Emily Klimevski; Gayani S Tennakoon; Amit Khot; Simon Harrison; Leon J Worth; Michelle K Yong; Monica A Slavin; Benjamin W Teh

doi:10.1093/ofid/ofad497

High Rates of Seroprotection and Seroconversion to Vaccine-Preventable Infections in the Early Post-Autologous Stem Cell Transplant Period

Open Forum Infect Dis. 2023 Oct 5;10(10):ofad497. doi: 10.1093/ofid/ofad497. eCollection 2023 Oct.

Authors

Victoria G Hall^{1

2}, Natalie R Saunders², Emily Klimevski², Gayani S Tennakoon², Amit Khot^{1

3}, Simon Harrison^{1

3}, Leon J Worth^{1

2}, Michelle K Yong^{1

2

4}, Monica A Slavin^{1

2

4}, Benjamin W Teh^{1

2}

Affiliations

¹ Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia.
² Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Australia.
³ Department of Clinical Hematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.
⁴ Department of Infectious Diseases, Royal Melbourne Hospital, Parkville, Australia.

Abstract

In patients early post-autologous stem cell transplant, seroprotection rates were high for Hemophilus influenzae type B and tetanus toxoid (70%-90%) but lower for Streptococcus pneumoniae (30%-50%) including after revaccination. There were high rates of seropositivity (67%-86%) to measles, mumps, and rubella and varicella zoster virus. Durability of protection requires assessment.

Keywords: autologous stem cell transplant; seroconversion; seroprotection; vaccination.