Integrating innate and adaptive immunity in oncolytic virus therapy

Abstract

Oncolytic viruses (OVs), viruses engineered to lyse tumor cells, work hand in hand with the immune response. While for decades the field isolated lytic capability and viral spread to increase response to virotherapy, there is now a wealth of research that demonstrates the importance of immunity in the OV mechanism of action. In this review, we will cover how OVs interact with the innate immune system to fully activate the adaptive immune system and yield exceptional tumor clearances as well as look forward at combination therapies which can improve clinical responses.

Keywords: adjuvant therapy; bioengineering; immunosuppression; immunotherapy; oncolytic virus; synthetic biology.