Association of triglyceride-glucose index levels with gestational diabetes mellitus in the US pregnant women: a cross-sectional study

Yan Zeng; Li Yin; Xiaoping Yin; Danqing Zhao

doi:10.3389/fendo.2023.1241372

Association of triglyceride-glucose index levels with gestational diabetes mellitus in the US pregnant women: a cross-sectional study

Front Endocrinol (Lausanne). 2023 Oct 10:14:1241372. doi: 10.3389/fendo.2023.1241372. eCollection 2023.

Authors

Yan Zeng^{1

2}, Li Yin¹, Xiaoping Yin¹, Danqing Zhao¹

Affiliations

¹ Department of Obstetrics and Gynecology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
² Guiyang Maternal and Child Health Care Hospital, Guiyang Children's Hospital, Guizhou Medical University, Guiyang, China.

Abstract

Objective: This investigation aimed to assess the correlation between the triglyceride-glucose (TyG) index and gestational diabetes mellitus (GDM) in pregnant women in the United States.

Methods: We calculated the TyG index utilizing data from pregnant women who participated in the National Health and Nutrition Examination Survey (NHANES) through 1999 to March 2020, and then employed multivariate logistic regression, smoothed curve fitting, and subgroup analysis to investigate the association between the TyG index and gestational diabetes during pregnancy.

Results: Logistic regression models revealed a positive association between the TyG index and GDM, remaining significant even after adjusting for all confounding variables (OR=3.43, 95% CI: 1.20-9.85, P = 0.0216). Subgroup analysis demonstrated consistent correlations and showed that there is no difference in the TyG index among first trimester subgroup. The TyG index had limited diagnostic efficacy for GDM (AUC=0.57, 95% CI: 0.50-0.63).

Conclusion: The TyG index correlates positively with the GDM, however its diagnostic efficacy is limited. Further research on the TyG index as an early predictor of GDM is required.

Keywords: NHANES; cross-sectinal study; gestational diabetes mellitus; insulin resistance; triglyceride-glucose index.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cross-Sectional Studies
Diabetes, Gestational* / diagnosis
Diabetes, Gestational* / epidemiology
Female
Glucose
Humans
Nutrition Surveys
Pregnancy
Pregnant Women
Triglycerides

Substances

Glucose
Triglycerides

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 81960284) and Guizhou Provincial Science and Technology Program (No:2022183).