The roles of T cells in psoriasis

Peng Zhang; Yuwen Su; Siying Li; Hui Chen; Ruifang Wu; Haijing Wu

doi:10.3389/fimmu.2023.1081256

The roles of T cells in psoriasis

Front Immunol. 2023 Oct 24:14:1081256. doi: 10.3389/fimmu.2023.1081256. eCollection 2023.

Authors

Peng Zhang¹, Yuwen Su¹, Siying Li¹, Hui Chen¹, Ruifang Wu¹, Haijing Wu¹

Affiliation

¹ Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Abstract

Psoriasis is a recurring inflammatory skin condition characterized by scaly, red patches on the skin. It affects approximately 3% of the US population and is associated with histological changes such as epidermal hyperplasia, increased blood vessel proliferation, and infiltration of leukocytes into the skin's dermis. T cells, which are classified into various subtypes, have been found to play significant roles in immune-mediated diseases, particularly psoriasis. This paper provides a review of the different T lymphocyte subtypes and their functions in psoriasis, as well as an overview of targeted therapies for treating psoriasis.

Keywords: T lymphocytes; cytokines; immunology; psoriasis; targeted therapies.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hyperplasia / pathology
Psoriasis* / pathology
Skin / pathology
Skin Diseases* / pathology
T-Lymphocytes / pathology

Grants and funding

This article was funded by the National Nature Science Foundation of China (NO.81903223 and NO.82173425), and the Nature Science Foundation of Hunan (NO.2022JJ40716 and NO.2020JJ2055).