Relating stability of individual dynamical networks to change in psychopathology

PLoS One. 2023 Nov 9;18(11):e0293200. doi: 10.1371/journal.pone.0293200. eCollection 2023.

Abstract

One hypothesis flowing from the network theory of psychopathology is that symptom network structure is associated with psychopathology severity and in turn, one may expect that individual network structure changes with the level of psychopathology severity. However, this expectation has rarely been addressed directly. This study aims to examine (1) the stability of individual contemporaneous symptom networks over a one-year period and (2) whether network stability is associated with a change in psychopathology. We used daily diary data of n = 66 individuals, located along the psychosis severity continuum, from two separate 90-day periods, one year apart (t = 180). Based on the newly developed Individual Network Invariance Test (INIT) to assess symptom-network stability, participants were divided into two groups with stable and unstable networks and we tested whether these groups differed in their absolute change in psychopathology severity. The majority of the sample (n = 51, 77.3%) showed a stable network over time while most individuals showed a decrease in psychopathological severity. We found no significant association between a change in psychopathology severity and individual network stability. Our results call for further critical evaluation of the association between networks and psychopathology to optimize the implementation of clinical applications based on current methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Psychopathology*
  • Psychotic Disorders*

Grants and funding

This work was supported by a Research Talent Grant (no. 406-18-532) from the Netherlands Organization for Scientific Research (NWO; https://www.nwo.nl/en) awarded to RHA Hoekstra, a European Research Council Consolidator Grant (no. 647209; https://erc.europa.eu/homepage); and NWO Vici Grant (no. VI.C.181.029; https://www.nwo.nl/en) awarded to D Borsboom, and a NWO Veni Grant (no. 016.156.019; https://www.nwo.nl/en) awarded to JTW Wigman. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.