RNA Splicing in Cancer and Targeted Therapies

Md Rafikul Islam; Preeti Nagar; Shegufta Tasneem Neetole; Ledong Wan; Mohammad Alinoor Rahman

doi:10.3390/genes14112020

RNA Splicing in Cancer and Targeted Therapies

Genes (Basel). 2023 Oct 29;14(11):2020. doi: 10.3390/genes14112020.

Authors

Md Rafikul Islam^{1

2}, Preeti Nagar^{1

2}, Shegufta Tasneem Neetole¹, Ledong Wan³, Mohammad Alinoor Rahman^{1

2}

Affiliations

¹ Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
² Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
³ Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Abstract

Since the discovery of RNA splicing as a fundamental step to remove introns from pre-mRNA to produce mature mRNAs, substantial research in the past decades has highlighted RNA splicing as a critical mediator of gene expression and proteome diversity, also being important in many developmental and biological processes [...].

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Introns / genetics
Neoplasms* / drug therapy
Neoplasms* / genetics
RNA Precursors / genetics
RNA Precursors / metabolism
RNA Splicing* / genetics
RNA, Messenger / genetics
RNA, Messenger / metabolism

Substances

RNA Precursors
RNA, Messenger

Grants and funding

M.A.R. was supported by the Edward P. Evans Foundation, the Winthrop P. Rockefeller Cancer Institute, and the Arkansas Breast Cancer Research Program.