Rhodopsin orphan GPCR20 interacts with neuropeptides and directs growth, sexual differentiation, and egg production in female Schistosoma mansoni

Microbiol Spectr. 2024 Jan 11;12(1):e0219323. doi: 10.1128/spectrum.02193-23. Epub 2023 Dec 4.

Abstract

Schistosomes cause schistosomiasis, one of the neglected tropical diseases as defined by the WHO. For decades, the treatment of schistosomiasis relies on a single drug, praziquantel. Due to its wide use, there is justified fear of resistance against this drug, and a vaccine is not available. Besides its biological relevance in signal transduction processes, the class of G protein-coupled receptors (GPCRs) is also well suited for drug design. Against this background, we characterized one GPCR of Schistosoma mansoni, SmGPCR20, at the molecular and functional level. We identified two potential neuropeptides (NPPs) as ligands, SmNPP26 and SmNPP40, and unraveled their roles, in combination with SmGPCR20, in neuronal processes controlling egg production, oogenesis, and growth of S. mansoni females. Since eggs are closely associated with the pathogenesis of schistosomiasis, our results contribute to the understanding of processes leading to egg production in schistosomes, which is under the control of pairing in this exceptional parasite.

Keywords: G protein-coupled receptor; membrane-anchored ligand and receptor yeast two-hybrid system; neuronal signaling; neuropeptide; schistosomes.

MeSH terms

  • Animals
  • Female
  • Rhodopsin
  • Schistosoma mansoni
  • Schistosomiasis mansoni* / parasitology
  • Schistosomiasis mansoni* / pathology
  • Schistosomiasis*
  • Sex Differentiation

Substances

  • Rhodopsin