Validation of COPD Population Screener Questionnaire in Chinese Population: A National Multicenter Study

Zijie Zhan; Yiming Ma; Yahong Chen; Jing Zhang; Wen Li; Zhiyi He; Jungang Xie; Haijin Zhao; Anping Xu; Kun Peng; Gang Wang; Qingping Zeng; Ting Yang; Yan Chen; Chen Wang

doi:10.1159/000535368

Validation of COPD Population Screener Questionnaire in Chinese Population: A National Multicenter Study

Respiration. 2023;102(12):995-1002. doi: 10.1159/000535368. Epub 2023 Dec 4.

Authors

Zijie Zhan^{1

2

3

4}, Yiming Ma^{1

2

3

4}, Yahong Chen⁵, Jing Zhang⁶, Wen Li⁷, Zhiyi He⁸, Jungang Xie⁹, Haijin Zhao¹⁰, Anping Xu¹¹, Kun Peng¹², Gang Wang¹³, Qingping Zeng¹⁴, Ting Yang^{15

16

17

18

19}, Yan Chen^{1

2

3

4}, Chen Wang^{15

16

17

18

19

20

21}

Affiliations

¹ Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
² Research Unit of Respiratory Diseases, Central South University, Changsha, China.
³ Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, Changsha, China.
⁴ Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, China.
⁵ Department of Respiratory and Critical Care Medicine, Third Hospital of Peking University, Beijing, China.
⁶ Department of Respiratory and Critical Care Medicine, Zhongshan Hospital of Fudan University, Shanghai, China.
⁷ Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
⁸ Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
⁹ Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
¹⁰ Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
¹¹ Department of Respiratory and Critical Care Medicine, Yingcheng People's Hospital, Yingcheng, China.
¹² Department of Respiratory and Critical Care Medicine, Sixth Hospital of Beijing, Beijing, China.
¹³ Department of Respiratory and Critical Care Medicine, Anji People's Hospital, Huzhou, China.
¹⁴ Department of Intensive Care Unit, Longshan People's Hospital, Xiangxi, China.
¹⁵ Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
¹⁶ Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
¹⁷ National Clinical Research Center for Respiratory Disease, Beijing, China.
¹⁸ National Center for Respiratory Medicine, Beijing, China.
¹⁹ Chinese Alliance for Respiratory Diseases in Primary Care, Beijing, China.
²⁰ Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
²¹ Department of Respiratory Medicine, Capital Medical University, Beijing, China.

PMID: 38048758
DOI: 10.1159/000535368

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is highly prevalent and underdiagnosed worldwide. The validity and reliability of COPD Population Screening (COPD-PS) questionnaire are not properly known in a large-sample Chinese population.

Methods: This is a national multicenter prospective study that enrolled 1,824 outpatients from 12 hospital sites in China. Scores of the Chinese version of COPD-PS questionnaire, demographic data, and clinical information were collected. The validity and the test-retest reliability were evaluated.

Results: 1,824 participants were involved in this study, and 404 (22.1%) were diagnosed with COPD. The overall area under the curve (AUC) of the receiver operating characteristic (ROC) for COPD-PS questionnaire was 0.761 (95% CI: 0.734-0.787). A cut-off point of 4 was recommended, corresponding to a sensitivity of 74.50% and a specificity of 64.37%. The COPD-PS questionnaire showed an overall Pearson's correlation of 0.88.

Conclusions: The COPD-PS questionnaire can be used in screening COPD patients from the general Chinese population with respiratory symptoms.

Keywords: COPD-PS; Chronic obstructive pulmonary disease; Questionnaire; Validation.

Publication types

Multicenter Study

MeSH terms

Humans
Mass Screening
Prospective Studies
Pulmonary Disease, Chronic Obstructive* / diagnosis
Pulmonary Disease, Chronic Obstructive* / epidemiology
Reproducibility of Results
Surveys and Questionnaires