BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

Yu Meng; Hui-Yan Sun; Yi He; Qian Zhou; Yi-Huang Liu; Hui Su; Ming-Zhu Yin; Fu-Rong Zeng; Xiang Chen; Guang-Tong Deng

doi:10.1186/s40779-023-00497-1

BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

Mil Med Res. 2023 Dec 4;10(1):61. doi: 10.1186/s40779-023-00497-1.

Authors

Yu Meng^#^{1

2

3

4

5}, Hui-Yan Sun^#^{1

2

3

4

5

6}, Yi He^#^{1

2

3

4

5}, Qian Zhou^{1

2

3

4

5}, Yi-Huang Liu^{1

2

3

4

5}, Hui Su^{1

2

3

4

5}, Ming-Zhu Yin^{1

2

3

4

5}, Fu-Rong Zeng⁷, Xiang Chen^{8

9

10

11

12}, Guang-Tong Deng^{13

14

15

16

17}

Affiliations

¹ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
² National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, 410008, China.
³ Furong Laboratory, Changsha, 410008, China.
⁴ Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, 410008, China.
⁶ Department of Breast Reconstruction, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300202, China.
⁷ Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China. zengflorachn@hotmail.com.
⁸ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China. chenxiangck@126.com.
⁹ National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, 410008, China. chenxiangck@126.com.
¹⁰ Furong Laboratory, Changsha, 410008, China. chenxiangck@126.com.
¹¹ Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, 410008, China. chenxiangck@126.com.
¹² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, 410008, China. chenxiangck@126.com.
¹³ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China. dengguangtong@outlook.com.
¹⁴ National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, 410008, China. dengguangtong@outlook.com.
¹⁵ Furong Laboratory, Changsha, 410008, China. dengguangtong@outlook.com.
¹⁶ Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, 410008, China. dengguangtong@outlook.com.
¹⁷ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, 410008, China. dengguangtong@outlook.com.

^# Contributed equally.

No abstract available

Keywords: AKR1C2; Bromodomain and extra terminal domain (BET) inhibitor; Cell death; Ferroptosis; Immunotherapy; Melanoma.

Publication types

Letter

MeSH terms

Antineoplastic Agents* / pharmacology
Antineoplastic Agents* / therapeutic use
Ferroptosis*
Humans
Hydroxysteroid Dehydrogenases
Immunotherapy
Melanoma* / drug therapy

Substances

Antineoplastic Agents
AKR1C2 protein, human
Hydroxysteroid Dehydrogenases

Publication types

MeSH terms

Substances

Grants and funding