Variovorax durovernensis sp. nov., a novel species isolated from an infected prosthetic aortic graft in a human

Int J Syst Evol Microbiol. 2023 Dec;73(12). doi: 10.1099/ijsem.0.006184.

Abstract

A novel bacterial strain, GSTT-20T was isolated from an infected, prosthetic endovascular graft explanted from a shepherd in London, United Kingdom. This strain was an aerobic, catalase-positive, oxidase-negative, Gram-stain-negative, motile, curved rod. It grew on blood agar, chocolate agar and MacConkey agar incubated at 37 °C in an aerobic environment after 48 h, appearing as yellow, mucoid colonies. Analysis of the complete 16S rRNA gene sequence showed closest similarity to Variovorax paradoxus with 99.6 % identity and Variovorax boronicumulans with 99.5 % identity. Phylogenetic analysis of the 16S rRNA gene sequence and phylogenomic analysis of single nucleotide polymorphisms within 1530 core genes showed GSTT-20T forms a distinct lineage in the genus Variovorax of the family Comamonadaceae. In silico DNA-DNA hybridization assays against GSTT-20T were estimated at 32.1 % for V. boronicumulans and 31.9 % for V. paradoxus. Genome similarity based on average nucleotide identity was 87.50 % when comparing GSTT-20T to V. paradoxus. Based on these results, the strain represented a novel species for which the name Variovorax durovernensis sp. nov. was proposed. The type strain is GSTT-20T (NCTC 14621T=CECT 30390T).

Keywords: Betaproteobacteria; Comamonadaceae; Variovorax; soil bacteria; taxonomy.

MeSH terms

  • Agar
  • Bacterial Typing Techniques
  • Base Composition
  • Comamonadaceae*
  • DNA, Bacterial / genetics
  • Fatty Acids* / chemistry
  • Humans
  • Phospholipids / analysis
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA
  • Soil Microbiology

Substances

  • Fatty Acids
  • RNA, Ribosomal, 16S
  • Agar
  • DNA, Bacterial
  • Phospholipids