Preliminary analysis of immune-related markers in thymic carcinoid

J Transl Med. 2023 Dec 9;21(1):894. doi: 10.1186/s12967-023-04751-x.

Abstract

The immune-related microenvironment of thymic carcinoid has rarely been reported. We analyzed the expression of PD-L1 and VISTA, and the distribution of CD4+ T cells, CD8+ T cells and CD68+ macrophages in the thymic carcinoid by immunohistochemical staining, and showed the correlation between these markers and clinical survival, indicating the potential therapeutic prospects.

Keywords: Immune-related microenvironment; PD-L1; Thymic carcinoid; VISTA.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • B7-H1 Antigen / metabolism
  • CD8-Positive T-Lymphocytes* / metabolism
  • Carcinoid Tumor* / metabolism
  • Humans
  • Lymphocytes, Tumor-Infiltrating / metabolism
  • Prognosis
  • Tumor Microenvironment

Substances

  • B7-H1 Antigen