Prognostic value of CHA2DS2-VASc score for the long-term cardiovascular events after coronary artery bypass grafting

Abdulkadir Ercan; Orcun Gurbuz; Zekeriya Afsin Culhaoglu; Gencehan Kumtepe; Hakan Ozkan; Ahmet Yuksel; Serdar Ener

doi:10.5606/tgkdc.dergisi.2023.24964.

Prognostic value of CHA₂DS₂-VASc score for the long-term cardiovascular events after coronary artery bypass grafting

Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Oct 19;31(4):479-488. doi: 10.5606/tgkdc.dergisi.2023.24964.. eCollection 2023 Oct.

Authors

Abdulkadir Ercan¹, Orcun Gurbuz¹, Zekeriya Afsin Culhaoglu², Gencehan Kumtepe³, Hakan Ozkan⁴, Ahmet Yuksel⁵, Serdar Ener⁶

Affiliations

¹ Department of Cardiovascular Surgery, Istinye University Faculty of Medicine, Istanbul, Türkiye.
² Department of Cardiology, Istinye University Faculty of Medicine, Istanbul, Türkiye.
³ Department of Cardiovascular Surgery, Meddem Hospital, Isparta, Türkiye.
⁴ Department of Cardiology, Medicana Bursa Hospital, Bursa, Türkiye.
⁵ Department of Cardiovascular Surgery, Bursa University Faculty of Medicine, Bursa, Türkiye.
⁶ Department of Cardiovascular Surgery, Medicana Bursa Hospital, Bursa Türkiye.

Abstract

Background: This study aims to investigate the value of the CHA2DS2-VASc score in predicting long-term major cardiovascular events following coronary artery bypass grafting.

Methods: Between January 2008 and January 2010, a total of 559 patients (445 males, 114 females; mean age: 62.7±9.1 years; range, 35 to 84 years) who underwent elective coronary artery bypass grafting were retrospectively analyzed. At a mean of 10.7±3.1-year follow-up, major cardiovascular events were considered as the primary endpoint.

Results: The multivariate Cox hazard analysis identified the CHA₂DS₂-VASc score as an independent predictor of major cardiovascular events (hazard ratio: 1.615; 95% confidence interval: 1.038-2.511; p=0.034). The receiver operating characteristic curve analyses revealed that 3.5 was the most optimal cut-off value of the score predicting major cardiovascular events and the patients were divided into two groups accordingly. The Kaplan-Meier analysis demonstrated a significantly higher incidence of major cardiovascular events in proportion to a higher CHA₂DS₂-VASc score (p<0.001).

Conclusion: CHA₂DS₂-VASc score ≥4, which includes many risk factors for cardiovascular events, can be used as an independent predictor of long-term major cardiovascular events after coronary artery bypass grafting.

Keywords: CHA2DS2-VASc score; coronary artery bypass grafting; coronary artery disease; major cardiovascular event..