Fiber-deficient diets reprogram the microbiota

Bradley G Fitzgerald; Matthew T Sorbara

doi:10.1016/j.chom.2023.11.014

Fiber-deficient diets reprogram the microbiota

Cell Host Microbe. 2023 Dec 13;31(12):1950-1951. doi: 10.1016/j.chom.2023.11.014.

Authors

Bradley G Fitzgerald¹, Matthew T Sorbara²

Affiliations

¹ Department of Molecular and Cellular Biology, the University of Guelph, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada.
² Department of Molecular and Cellular Biology, the University of Guelph, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada. Electronic address: msorbara@uoguelph.ca.

PMID: 38096786
DOI: 10.1016/j.chom.2023.11.014

Abstract

Exclusive enteral nutrition, a diet lacking fiber, is used to treat pediatric Crohn's disease. In this issue of Cell Host & Microbe, Kuffa et al. find that a fiber-deficient diet thins the mucus layer and alters microbial cross-feeding, causing pro-inflammatory Mucispirillum to move away from the epithelium, which ameliorates colitis.

MeSH terms

Child
Crohn Disease* / therapy
Diet
Dietary Fiber
Enteral Nutrition
Humans
Microbiota*

Substances

Dietary Fiber