Oncogene-induced senescence in meningiomas-an immunohistochemical study

J Neurooncol. 2024 Jan;166(1):143-153. doi: 10.1007/s11060-023-04532-y. Epub 2023 Dec 20.

Abstract

Purpose: Meningiomas are tumours originating from meningothelial cells, the majority belonging to grade 1 according to the World Health Organization classification of the tumours of the Central Nervous System. Factors contributing to the progression to the higher grades (grades 2 and 3) have not been elucidated yet. Senescence has been proposed as a potential mechanism constraining the malignant transformation of tumours. Senescence-associated beta-galactosidase (SA-β-GAL) and inhibitors of cyclin-dependent kinases p16 and p21 have been suggested as senescence markers.

Methods: We analysed 318 meningiomas of total 343 (178 grade 1, 133 grade 2 and 7 grade 3). Tissue microarrays were constructed and stained immunohistochemically, using antibodies for SA-β-GAL, p16 and p21.

Results: The positive correlation of the tumour grade with the expression of p16 (p = 0.016) and SA-β-GAL (p = 0.002) was observed. The expression of p16 and SA-β-GAL was significantly higher in meningiomas grade 2 compared to meningiomas grade 1 (p = 0.006 and p = 0.004, respectively). SA-β-GAL positivity positively correlated with p16 and p21 in the whole cohort. In grade 2 meningiomas, a positive correlation was only between SA-β-GAL and p16. Correlations of senescence markers in meningiomas grade 2 were not present.

Conclusion: Our findings suggest the senescence activation in meningiomas grade 2 as a potential mechanism for the restraining of tumour growth and give hope for applying of promising senolytic therapy.

Keywords: Atypical meningioma; Beta-galactosidase; Grade 2 meningioma; Senescence; p16; p21.

MeSH terms

  • Cellular Senescence / physiology
  • Central Nervous System / chemistry
  • Central Nervous System / metabolism
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism
  • Humans
  • Meningeal Neoplasms*
  • Meningioma*
  • Oncogenes
  • beta-Galactosidase / metabolism

Substances

  • beta-Galactosidase
  • Cyclin-Dependent Kinase Inhibitor p16