Probing ligand selectivity in pathogens

Bryan VanSchouwen; Giuseppe Melacini

doi:10.7554/eLife.94720

Probing ligand selectivity in pathogens

Elife. 2023 Dec 21:12:e94720. doi: 10.7554/eLife.94720.

Authors

Bryan VanSchouwen¹, Giuseppe Melacini²

Affiliations

¹ Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Canada.
² Department of Chemistry and Chemical Biology, and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

Abstract

Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?

Keywords: L. donovani; Protein kinase A; T. brucei; T. cruzi; biochemistry; chemical biology; infectious disease; ligand selectivity; microbiology; trypanosomatid pathogens.

Publication types

Editorial

MeSH terms

Cyclic AMP-Dependent Protein Kinases / metabolism
Leishmania donovani*
Ligands
Phosphotransferases / metabolism
Purine Nucleosides / metabolism
Trypanosoma brucei brucei*

Substances

Ligands
Phosphotransferases
Cyclic AMP-Dependent Protein Kinases
Purine Nucleosides