Mitochondrial damage-associated molecular patterns in chronic obstructive pulmonary disease: Pathogenetic mechanism and therapeutic target

Yongchun Shen; Lei Chen; Jun Chen; Jiangyue Qin; Tao Wang; Fuqiang Wen

doi:10.2478/jtim-2022-0019

Mitochondrial damage-associated molecular patterns in chronic obstructive pulmonary disease: Pathogenetic mechanism and therapeutic target

J Transl Int Med. 2022 Jun 10;11(4):330-340. doi: 10.2478/jtim-2022-0019. eCollection 2023 Dec.

Authors

Yongchun Shen¹, Lei Chen¹, Jun Chen¹, Jiangyue Qin¹, Tao Wang¹, Fuqiang Wen¹

Affiliation

¹ Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, Sichuan Province, China.

Abstract

Chronic obstructive pulmonary disease (COPD) is a common inflammatory airway disease characterized by enhanced inflammation. Recent studies suggest that mitochondrial damage-associated molecular patterns (DAMPs) may play an important role in the regulation of inflammation and are involved in a serial of inflammatory diseases, and they may also be involved in COPD. This review highlights the potential role of mitochondrial DAMPs during COPD pathogenesis and discusses the therapeutic potential of targeting mitochondrial DAMPs and their related signaling pathways and receptors for COPD. Research progress on mitochondrial DAMPs may enhance our understanding of COPD inflammation and provide novel therapeutic targets.

Keywords: chronic obstructive pulmonary disease; inflammation; mitochondrial damage-associated molecular patterns.

Grants and funding

This work was supported by the National Natural Science Foundation of China (31871157, 81830001, and 82170046), 1•3•5 Project for Disciplines of Excellence, West China Hospital of Sichuan University (ZYGD18006, ZYJC18012) and Sichuan Key Research and Development Program (2020YFS0147).