Next generation sequencing-based identification of fusion-driven renal neoplasia: A single institution experience

Burak Tekin; Christopher D Hofich; Beth A Pitel; J Kenneth Schoolmeester; Rumeal D Whaley; Aditya Raghunathan; Kingsley Ebare; Melissa L Stanton; Jordan P Reynolds; Vidit Sharma; R Houston Thompson; Stephen A Boorjian; Bradley C Leibovich; Loren P Herrera Hernandez; Rafael E Jimenez; John C Cheville; Rhett P Ketterling; Katherine B Geiersbach; Patricia T Greipp; William R Sukov; Benjamin R Kipp; Kevin C Halling; Sounak Gupta

doi:10.1016/j.humpath.2023.12.006

Next generation sequencing-based identification of fusion-driven renal neoplasia: A single institution experience

Hum Pathol. 2024 Oct:152:105542. doi: 10.1016/j.humpath.2023.12.006. Epub 2023 Dec 23.

Authors

Burak Tekin¹, Christopher D Hofich², Beth A Pitel³, J Kenneth Schoolmeester⁴, Rumeal D Whaley⁵, Aditya Raghunathan⁶, Kingsley Ebare⁷, Melissa L Stanton⁸, Jordan P Reynolds⁹, Vidit Sharma¹⁰, R Houston Thompson¹¹, Stephen A Boorjian¹², Bradley C Leibovich¹³, Loren P Herrera Hernandez¹⁴, Rafael E Jimenez¹⁵, John C Cheville¹⁶, Rhett P Ketterling¹⁷, Katherine B Geiersbach¹⁸, Patricia T Greipp¹⁹, William R Sukov²⁰, Benjamin R Kipp²¹, Kevin C Halling²², Sounak Gupta²³

Affiliations

¹ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Tekin.Burak@mayo.edu.
² Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Hofich.Christopher@mayo.edu.
³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Pitel.Beth@mayo.edu.
⁴ Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA. Electronic address: Schoolmeester.J@mayo.edu.
⁵ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Whaley.Rumeal@mayo.edu.
⁶ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Raghunathan.Aditya@mayo.edu.
⁷ The Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ, USA. Electronic address: Ebare.Kingsley@mayo.edu.
⁸ The Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ, USA. Electronic address: Stanton.Melissa1@mayo.edu.
⁹ Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA. Electronic address: Reynolds.Jordan@mayo.edu.
¹⁰ The Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address: Sharma.Vidit@mayo.edu.
¹¹ The Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address: Thompson.Robert@mayo.edu.
¹² The Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address: Boorjian.Stephen@mayo.edu.
¹³ The Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address: leibovich.bradley@mayo.edu.
¹⁴ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: HerreraHernandez.Loren@mayo.edu.
¹⁵ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Jimenez.Rafael@mayo.edu.
¹⁶ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Cheville.John@mayo.edu.
¹⁷ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Ketterling.Rhett@mayo.edu.
¹⁸ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Geiersbach.Katherine@mayo.edu.
¹⁹ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Greipp.Patricia@mayo.edu.
²⁰ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Sukov.William@mayo.edu.
²¹ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Kipp.Benjamin@mayo.edu.
²² Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Halling.Kevin@mayo.edu.
²³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: gupta.sounak@mayo.edu.

PMID: 38145826
DOI: 10.1016/j.humpath.2023.12.006

No abstract available

Keywords: Gene fusion; Gene rearrangement; Next generation sequencing; Renal cell carcinoma; Renal neoplasia.

Publication types

Letter

MeSH terms

Adult
Aged
Biomarkers, Tumor / analysis
Biomarkers, Tumor / genetics
Carcinoma, Renal Cell / genetics
Carcinoma, Renal Cell / pathology
Female
High-Throughput Nucleotide Sequencing*
Humans
Kidney Neoplasms* / genetics
Kidney Neoplasms* / pathology
Male
Middle Aged
Oncogene Proteins, Fusion / genetics

Substances

Oncogene Proteins, Fusion
Biomarkers, Tumor