Ni-Catalyzed Stereoconvergent Reductive Dimerization of Bromocyclobutenes

Org Lett. 2024 Jan 12;26(1):355-359. doi: 10.1021/acs.orglett.3c03909. Epub 2023 Dec 26.

Abstract

A nickel-catalyzed reductive dimerization of bromocyclobutenes to produce unusual and unprecedented cyclobutene dimers was developed. In a stereoconvergent procedure, various bromocyclobutenes were readily dimerized in good yields, with good diastereoselectivities and broad functional group tolerance. Notably, the presence of a carbonyl group in the starting material appears to dictate diastereoselectivity.