H2S serves as the immunoregulatory essence of apoptotic cell death

Christopher Hine; András K Ponti; María Ángeles Cáliz-Molina; Alejandro Martín-Montalvo

doi:10.1016/j.cmet.2023.12.006

H₂S serves as the immunoregulatory essence of apoptotic cell death

Cell Metab. 2024 Jan 2;36(1):3-5. doi: 10.1016/j.cmet.2023.12.006.

Authors

Christopher Hine¹, András K Ponti², María Ángeles Cáliz-Molina³, Alejandro Martín-Montalvo⁴

Affiliations

¹ Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA. Electronic address: hinec@ccf.org.
² Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.
³ Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA; Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092 Seville, Spain.
⁴ Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092 Seville, Spain; Biomedical Research Network on Diabetes and Related Metabolic Diseases-CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain.

PMID: 38171337
DOI: 10.1016/j.cmet.2023.12.006

Abstract

Apoptosis supports tissue homeostasis and prevents immune disorders by removing damaged and functionally aberrant cells. Here, Ou et al. utilized genetic, pharmacological, and proteomic approaches focused on sulfur amino acid catabolism to discover that hydrogen sulfide (H₂S) release during apoptosis suppresses Th17 cell differentiation, thus providing therapeutic targets for autoimmune diseases.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Apoptosis
Homeostasis
Hydrogen Sulfide* / metabolism
Hydrogen Sulfide* / pharmacology
Proteomics*

Substances

Hydrogen Sulfide

Abstract

Publication types

MeSH terms

Substances

Grants and funding