Long-term oncological outcomes of robotic versus laparoscopic gastrectomy for gastric cancer: multicentre cohort study

Br J Surg. 2024 Jan 3;111(1):znad435. doi: 10.1093/bjs/znad435.

Abstract

Background: The aim of this multicentre cohort study was to compare the long-term oncological outcomes of robotic gastrectomy (RG) and laparoscopic gastrectomy (LG) for patients with gastric cancer.

Methods: Patients with gastric cancer who underwent radical gastrectomy by robotic or laparoscopic approaches from 1 March 2010 to 31 December 2018 at 10 high-volume centres in China were selected from institutional databases. Patients receiving RG were matched 1 : 1 by propensity score with patients undergoing LG. The primary outcome was 3-year disease-free survival. Secondary outcomes were overall survival and disease recurrence.

Results: Some 2055 patients who underwent RG and 4309 patients who had LG were included. The propensity score-matched cohort comprised 2026 RGs and 2026 LGs. Median follow-up was 41 (i.q.r. 39-58) months for the RG group and 39 (38-56) months for the LG group. The 3-year disease-free survival rates were 80.8% in the RG group and 79.5% in the LG group (log rank P = 0.240; HR 0.92, 95% c.i. 0.80 to 1.06; P = 0.242). Three-year OS rates were 83.9 and 81.8% respectively (log rank P = 0.068; HR 0.87, 0.75 to 1.01; P = 0.068) and the cumulative incidence of recurrence over 3 years was 19.3% versus 20.8% (HR 0.95, 0.88 to 1.03; P = 0.219), with no difference between groups.

Conclusion: RG and LG in patients with gastric cancer are associated with comparable disease-free and overall survival.

Publication types

  • Multicenter Study

MeSH terms

  • Cohort Studies
  • Gastrectomy
  • Humans
  • Laparoscopy*
  • Levamisole / analogs & derivatives*
  • Postoperative Complications / etiology
  • Postoperative Complications / surgery
  • Propensity Score
  • Retrospective Studies
  • Robotic Surgical Procedures*
  • Stomach Neoplasms* / surgery
  • Treatment Outcome

Substances

  • 3-aminolevamisole
  • Levamisole