The endocannabinoid system, an important biological network for maintaining and balancing various functions of the human body, is involved in many physiological functions such as pain, emotion, learning and memory, etc. Among which the endocannabinoid receptors ［including type I (CB1) and type II (CB2) receptors］ play an important role in the regulation of pain and have become an important target in the mechanism research of acupuncture analgesia. CB1 is mainly distributed in the central nervous system, including the spinal cord, cerebral cortex, amygdala, insular cortex, and basal ganglia, etc. CB2 is mainly distributed in peripheral immune tissues, such as spleen, bone, skin, etc. In the central and peripheral nervous systems, acupuncture can activate CB1 and CB2 receptors respectively, which is involved in the transmission of central nociceptive signals and related transmitters as well as the peri-pheral pro-nociceptive inflammatory response, thereby alleviating the nociceptive hypersensitivity in animal models. In this paper, we systematically summarize the roles of the above mechanisms in different types of animal models (inflammatory pain, neuropathological pain, visceral pain, etc.), so as to provide new ideas for the study of the underlying mechanisms of acupuncture analgesia.
内源性大麻素系统作为维持和平衡人体各项机能的重要生物网络，参与疼痛、情绪、学习记忆等多项生理功能，其中内源性大麻素受体（包括Ⅰ型、Ⅱ型）在疼痛的调控中发挥着重要的作用，也成为针刺镇痛机制研究中的重要靶点。在中枢和外周神经系统中，针刺可以分别激活大麻素Ⅰ型受体和Ⅱ型受体，参与到中枢痛觉信号和相关递质的传导以及外周与疼痛相关的炎性反应中，进而缓解模型动物的痛觉超敏。本文系统总结了上述机制在不同类型动物模型中的作用，以期为针刺镇痛机制研究提供新思路。.
Keywords: Acupuncture analgesia; Animal experiment; Endocannabinoid receptors; Endocannabinoid system; Review.