Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study

Xue-Min Jia; Ting-Ting Deng; Hang Su; Hao-Jun Shi; Hao Qin; Gong-Chang Yu; Ying Yin; Fan-Jie Liu; Bin Shi

doi:10.3389/fgene.2023.1340245

Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study

Front Genet. 2024 Jan 8:14:1340245. doi: 10.3389/fgene.2023.1340245. eCollection 2023.

Authors

Xue-Min Jia^{1

2}, Ting-Ting Deng³, Hang Su⁴, Hao-Jun Shi⁵, Hao Qin², Gong-Chang Yu¹, Ying Yin⁶, Fan-Jie Liu^{1

2}, Bin Shi^{1

2}

Affiliations

¹ Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
² Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
³ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁴ College of Rehabilitation, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
⁵ School of TCM, Macau University of Science and Technology, Macau, China.
⁶ Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Abstract

Background: Previous studies demonstrated a controversial relationship between sarcopenia (SP) and osteoarthritis (OA) and their genetic causality is unclear. Thus, we conducted a Mendelian randomization (MR) analysis to evaluate the possible causal association between sarcopenia-related traits (appendicular lean mass (ALM), grip strength, usual walking pace) and OA. Method: We used pooled genetic data from the UK Biobank for ALM(n = 450,243), left-hand grip strength (n = 461,026), right-hand grip strength (n = 461,089) and usual walking pace (n = 459,915). Moreover, summary statistics for OA were obtained from the latest study conducted by the Genetics of Osteoarthritis Consortium, including all OA (n = 826,690), hand OA (n = 303,7782), hip OA (n = 353,388) and knee OA (n = 396,054). The primary method for estimating causal effects was the inverse-variance weighted (IVW) method, with the utilizing of false discovery rate adjusted p values (P _FDR). Additional MR methods such as MR-Egger regression, MR pleiotropy residual sum and outlier (MR-PRESSO), weighted median were employed as supplementary analyses. Results: We discovered ALM (odds ratio (OR) = 1.103, 95% confidence interval (CI) = 1.052-1.156, P _FDR = 2.87E-04), hand grip strength (left, IVW OR = 0.823, 95% CI = 0.712 to 0.952, P _FDR = 0.020; right, OR = 0.826, 95% CI = 0.718 to 0.950, P _FDR = 0.020), and usual walking pace (OR = 0.339, 95% CI = 0.204 to 0.564, P _FDR = 2.38E-04) were causally associated with OA risk. In the reverse MR analysis, we identified a causal effect of OA on ALM (β = -0.258, 95% CI = -0.369 to 0.146, P _FDR = 0.6.07E-06), grip strength (left, β = -0.064, 95% CI = -0.104 to 0.024, P _FDR = 0.002; right, β = -0.055, 95% CI = -0.095 to 0.014, P _FDR = 0.008), and usual walking pace (β = -0.104, 95% CI = -0.147 to 0.061, P _FDR = 1.61E-05). Conclusion: This present study suggests an obvious causality of SP on OA, with condition exhibiting site-specific effects, while evidence was also provided for the causal effect of OA on SP.

Keywords: Mendelian randomization; causal relationship; degenerative musculoskeletal diseases; osteoarthritis; sarcopenia.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The key R&D Program of Shandong Province (2022CXGC020510) and the Academic Promotion Program of Shandong First Medical University (2019QL003) funded this study.