The Report Says What?: How the Medical Microbiologist can aid in the Interpretation of Next-Generation Sequencing Results

Cristina Costales; Jennifer Dien Bard

doi:10.1016/j.cll.2023.10.006

The Report Says What?: How the Medical Microbiologist can aid in the Interpretation of Next-Generation Sequencing Results

Clin Lab Med. 2024 Mar;44(1):75-84. doi: 10.1016/j.cll.2023.10.006. Epub 2023 Nov 14.

Authors

Cristina Costales¹, Jennifer Dien Bard²

Affiliations

¹ Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: ccostales@chla.usc.edu.
² Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

PMID: 38280799
DOI: 10.1016/j.cll.2023.10.006

Abstract

The applications of next-generation sequencing (NGS) in the clinical microbiology laboratory are expanding at a rapid pace. The medical microbiologist thus plays a key role in translating the results of these emerging technologies to the practicing clinician. Here we discuss the factors to consider to successfully develop standardized reporting for microbial targeted or metagenomic NGS testing in the clinical laboratory.

Keywords: Medical microbiology; Metagenomic next-generation sequencing; Tumor board.

Publication types

Review

MeSH terms

High-Throughput Nucleotide Sequencing* / methods
Metagenomics*