Elevated phase amplitude coupling as a depression biomarker in epilepsy

James J Young; Andy Ho Wing Chan; Nathalie Jette; Heidi A Bender; Adam E Saad; Ignacio Saez; Fedor Panov; Saadi Ghatan; Ji Yeoun Yoo; Anuradha Singh; Madeline C Fields; Lara V Marcuse; Helen S Mayberg

doi:10.1016/j.yebeh.2024.109659

Elevated phase amplitude coupling as a depression biomarker in epilepsy

Epilepsy Behav. 2024 Mar:152:109659. doi: 10.1016/j.yebeh.2024.109659. Epub 2024 Feb 1.

Authors

Affiliations

¹ Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: james.young@mssm.edu.
² Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: howing.chan@mountsinai.org.
³ Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: nathalie.jette@mssm.edu.
⁴ Weill Cornell Medicine, Department of Neurological Surgery, 525 East 68th Street, New York, NY 10021, USA.
⁵ Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: adam.saad@mssm.edu.
⁶ Departments of Neurocience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. Electronic address: ignacio.saez@mssm.edu.
⁷ Departments of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: fedor.panov@mountsinai.org.
⁸ Departments of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: saadi.ghatan@mountsinai.org.
⁹ Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: jiyeoun.yoo@mssm.edu.
¹⁰ Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: anuradha.singh@mssm.edu.
¹¹ Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: madeline.fields@mssm.edu.
¹² Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: lara.marcuse@mssm.edu.
¹³ Departments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Departments of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. Electronic address: helen.mayberg@mssm.edu.

PMID: 38301454
PMCID: PMC10923038 (available on 2025-03-01)
DOI: 10.1016/j.yebeh.2024.109659

Abstract

Depression is prevalent in epilepsy patients and their intracranial brain activity recordings can be used to determine the types of brain activity that are associated with comorbid depression. We performed case-control comparison of spectral power and phase amplitude coupling (PAC) in 34 invasively monitored drug resistant epilepsy patients' brain recordings. The values of spectral power and PAC for one-minute segments out of every hour in a patient's study were correlated with pre-operative assessment of depressive symptoms by Beck Depression Inventory-II (BDI). We identified an elevated PAC signal (theta-alpha-beta phase (5-25 Hz)/gamma frequency (80-100 Hz) band) that is present in high BDI scores but not low BDI scores adult epilepsy patients in brain regions implicated in primary depression, including anterior cingulate cortex, amygdala and orbitofrontal cortex. Our results showed the application of PAC as a network-specific, electrophysiologic biomarker candidate for comorbid depression and its potential as treatment target for neuromodulation.

Keywords: Comorbid Depression; Depression; Epilepsy; Intracranial EEG; Phase Amplitude Coupling; Spectral Power.

MeSH terms

Adult
Brain
Brain Waves* / physiology
Depression / diagnosis
Depression / etiology
Electroencephalography
Epilepsy* / complications
Epilepsy* / diagnosis
Humans
Prefrontal Cortex

Abstract

MeSH terms

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