Effect of Vaginal Microecological Disorders on the Increased Risk of Abnormal Cervical Cytology Among Women With Human Immunodeficiency Virus in China

J Infect Dis. 2024 Jul 25;230(1):61-66. doi: 10.1093/infdis/jiae058.

Abstract

Background: Abnormal cervical cytology is commonly observed in women with human immunodeficiency virus (WWH).

Methods: A cross-sectional study was conducted with 130 WWH and 147 age-matched healthy controls, who underwent gynecological examinations at Beijing Ditan Hospital. The presence of abnormal cervical cytology in WWH was predicted after performing a logistic regression analysis.

Results: Multivariate logistic regression revealed 3 independent factors, among which CD4 cell count ≥350 cells/μL was the protective factor, while human papillomavirus infection and abnormal vaginal pH were the risk factors.

Conclusions: Vaginal microecological disorders can increase the risk of abnormal cervical cytology in WWH.

Keywords: cervical cytology; human immunodeficiency virus; human papillomavirus; vaginal microecological disorders; women with HIV.

MeSH terms

  • Adult
  • CD4 Lymphocyte Count
  • Case-Control Studies
  • Cervix Uteri / pathology
  • Cervix Uteri / virology
  • China / epidemiology
  • Cross-Sectional Studies
  • Female
  • HIV Infections* / complications
  • Humans
  • Logistic Models
  • Middle Aged
  • Papillomavirus Infections* / complications
  • Papillomavirus Infections* / diagnosis
  • Papillomavirus Infections* / virology
  • Risk Factors
  • Vagina / pathology
  • Vagina / virology
  • Vaginal Diseases* / epidemiology
  • Vaginal Diseases* / virology
  • Young Adult