Background: Siponimod-related lymphopenia in real-world clinical practice has implications for dose adjustment and infection risk.
Objective: To characterise siponimod-related lymphopenia in people with secondary progressive multiple sclerosis (pwSPMS).
Methods: This is a retrospective cohort of 188 pwSPMS. The development of grade 4 lymphopenia was interrogated with Kaplan-Meier survival analysis and binary logistic regression.
Results: Lymphopenia develops soon after commencing siponimod. In total, 15 (8.5%) of 176 experienced grade 4 lymphopenia at 1 month after initiation. There were no clinically significant associations between patient characteristics and development of grade 4 lymphopenia.
Conclusion: Grade 4 lymphopenia can occur soon after siponimod initiation and cannot be predicted.
Keywords: Siponimod; lymphocyte; lymphopenia; secondary progressive multiple sclerosis.