Background: Acetyl hexapeptide-8, also known as Argireline, is a topical, short-acting, synthetic peptide that has recently gained popularity for its antiwrinkle effects. This agent has emerged as a more accessible alternative to botulinum neurotoxin.
Objective: This study evaluates the public interest in acetyl hexapeptide-8 in the United States from 2013 to 2023, as described by search volume on Google, the most-used search engine.
Methods: We analyzed the longitudinal relative monthly search volume from January 1, 2013, to January 1, 2023, for acetyl hexapeptide-related terms. We compared the internet search trends for "Botox" during this period to "Argireline."
Results: The terms "Argireline" and "Botox in a Bottle" both had substantial increases in search volume in 2022. Although its search volume is drastically increasing, "Argireline" was less searched than "Botox," which had a stable, up-trending search volume over the past decade.
Conclusions: The increasing interest in acetyl hexapeptide-8 may be due to its cost-effectiveness and use as a botulinum neurotoxin alternative. Affordability, over-the-counter availability, and ease of self-application of the agent suggest its potential to enhance accessibility to cosmetic dermatologic care.
Keywords: Argireline; BoNT; acetyl-hexapeptide-8; anti-aging; anti-wrinkle; botox; botulinum neurotoxin; cosmetic; cosmetic dermatology; dermatologist; dermatology; injectable neurotoxin; neurotoxin; skin specialist; topical; topical agent.
©Sofia Eva Olsson, Bhavana Sreepad, Trevor Lee, Manal Fasih, Arman Fijany. Originally published in JMIR Dermatology (http://derma.jmir.org), 20.02.2024.