Brain-wide human oscillatory local field potential activity during visual working memory

Balbir Singh; Zhengyang Wang; Leen M Madiah; S Elizabeth Gatti; Jenna N Fulton; Graham W Johnson; Rui Li; Benoit M Dawant; Dario J Englot; Sarah K Bick; Shawniqua Williams Roberson; Christos Constantinidis

doi:10.1016/j.isci.2024.109130

Brain-wide human oscillatory local field potential activity during visual working memory

iScience. 2024 Feb 5;27(3):109130. doi: 10.1016/j.isci.2024.109130. eCollection 2024 Mar 15.

Authors

Balbir Singh¹, Zhengyang Wang², Leen M Madiah¹, S Elizabeth Gatti¹, Jenna N Fulton³, Graham W Johnson⁴, Rui Li⁵, Benoit M Dawant⁵, Dario J Englot^{1

4}, Sarah K Bick^{1

4}, Shawniqua Williams Roberson^{1

3}, Christos Constantinidis^{1

2

6}

Affiliations

¹ Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
² Neuroscience Program, Vanderbilt University, Nashville, TN, USA.
³ Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴ Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
⁵ Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
⁶ Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

Abstract

Oscillatory activity in the local field potential (LFP) is thought to be a marker of cognitive processes. To understand how it differentiates tasks and brain areas in humans, we recorded LFPs in 15 adults with intracranial depth electrodes, as they performed visual-spatial and shape working memory tasks. Stimulus appearance produced widespread, broad-band activation, including in occipital, parietal, temporal, insular, and prefrontal cortex, and the amygdala and hippocampus. Occipital cortex was characterized by most elevated power in the high-gamma (100-150 Hz) range during the visual stimulus presentation. The most consistent feature of the delay period was a systematic pattern of modulation in the beta frequency (16-40 Hz), which included a decrease in power of variable timing across areas, and rebound during the delay period. These results reveal the widespread nature of oscillatory activity across a broad brain network and region-specific signatures of oscillatory processes associated with visual working memory.

Keywords: Biological sciences; Clinical neuroscience; Cognitive neuroscience; Natural sciences; Neuroscience; Sensory neuroscience; Systems neuroscience.

Abstract

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