Abstract
A 55-year-old white man was diagnosed in 1975 with Hodgkin's disease stage IIA, mixed cellularity. He was treated with 4,500 rads to an inverted-Y field followed by six cycles of MOPP and remained in complete remission. In 1983 a right axillary lymph node biopsy showed recurrent Hodgkin's disease, mixed cellularity. While receiving his initial chemotherapy he developed persistent epigastric distress. Endoscopic gastric biopsy demonstrated a diffuse large-cell non-Hodgkin's lymphoma. Surface marker studies confirmed the separate identity of these two malignant lymphoproliferative processes. This represents the first reported simultaneous occurrence of relapsing Hodgkin's disease with treatment-related non-Hodgkin's lymphoma.
Publication types
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Case Reports
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Combined Modality Therapy
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Hodgkin Disease / pathology
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Hodgkin Disease / therapy*
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Humans
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Lymphoma / etiology*
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Lymphoma / pathology
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Male
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Mechlorethamine / administration & dosage
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Mechlorethamine / adverse effects
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Middle Aged
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Neoplasms, Multiple Primary* / pathology
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Neoplasms, Radiation-Induced* / pathology
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Prednisone / administration & dosage
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Prednisone / adverse effects
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Procarbazine / administration & dosage
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Procarbazine / adverse effects
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Vincristine / administration & dosage
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Vincristine / adverse effects
Substances
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Procarbazine
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Mechlorethamine
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Vincristine
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Prednisone