Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates

Sanjay Chawla; Abbot R Laptook; Emily A Smith; Sylvia Tan; Girija Natarajan; Myra H Wyckoff; Rachel G Greenberg; Namasivayam Ambalavanan; Edward F Bell; Krisa P Van Meurs; Susan R Hintz; Betty R Vohr; Erika F Werner; Abhik Das; Seetha Shankaran; NICHD Neonatal Research Network

doi:10.1038/s41372-024-01905-7

Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates

J Perinatol. 2024 Jun;44(6):802-810. doi: 10.1038/s41372-024-01905-7. Epub 2024 Feb 23.

Authors

Collaborators

NICHD Neonatal Research Network:
Waldemar A Carlo, Anna Maria Hibbs, Stephanie Merhar, C Michael Cotten, Ravi M Patel, Tarah T Colaizy, Aaron Hamvas, Abhay J Bhatt, Janell Fuller, Sara DeMauro, Anup C Katheria, Robin K Ohls, Jon E Tyson

Affiliations

¹ Department of Pediatrics, Central Michigan University, Wayne State University, Children's Hospital of Michigan, Detroit, MI, USA. schawla@dmc.org.
² Department of Pediatrics, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
³ RTI International, Washington, DC, USA.
⁴ Department of Pediatrics, Central Michigan University, Wayne State University, Children's Hospital of Michigan, Detroit, MI, USA.
⁵ Department of Pediatrics, UT Southwestern Medical Center at Dallas, Dallas, TX, USA.
⁶ Department of Pediatrics, Duke University, Durham, NC, USA.
⁷ Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
⁸ Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
⁹ Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
¹⁰ Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA, USA.
¹¹ Social, Statistical, and Environmental Sciences Unit, RTI International, Rockville, MA, USA.
¹² Department of Pediatrics, University of Texas, Austin, TX, USA.

PMID: 38396053
DOI: 10.1038/s41372-024-01905-7

Abstract

Objective: To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI).

Methods: This retrospective cohort study included extremely preterm infants (gestational age 22^0/7-26^6/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years.

Results: Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models.

Conclusion: Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.

MeSH terms

Adult
Body Mass Index*
Cerebral Palsy
Child, Preschool
Female
Gestational Age*
Humans
Infant
Infant, Extremely Premature*
Infant, Newborn
Male
Neurodevelopmental Disorders / epidemiology
Neurodevelopmental Disorders / etiology
Obesity / complications
Pregnancy
Pregnancy Trimester, First*
Retrospective Studies

Abstract

MeSH terms

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