Small Molecule Allosteric Inhibitor of HIPK2 as a Novel Therapy against Kidney Fibrosis

J Am Soc Nephrol. 2024 Jun 1;35(6):809-811. doi: 10.1681/ASN.0000000000000327. Epub 2024 Feb 7.
No abstract available

MeSH terms

  • Allosteric Regulation
  • Animals
  • Carrier Proteins / antagonists & inhibitors
  • Carrier Proteins / metabolism
  • Fibrosis*
  • Humans
  • Kidney / drug effects
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney Diseases / drug therapy
  • Mice
  • Protein Serine-Threonine Kinases* / antagonists & inhibitors
  • Protein Serine-Threonine Kinases* / metabolism

Substances

  • Protein Serine-Threonine Kinases
  • HIPK2 protein, human
  • Carrier Proteins