Genetically determined telomere length and risk for haematologic diseases: results from large prospective cohorts and Mendelian Randomization analysis

Yang Li; Jia Chen; Ting Sun; Yunfei Chen; Rongfeng Fu; Xiaofan Liu; Feng Xue; Wei Liu; Mankai Ju; Xinyue Dai; Huan Dong; Huiyuan Li; Wentian Wang; Ying Chi; Lei Zhang

doi:10.1038/s41408-024-01035-5

Genetically determined telomere length and risk for haematologic diseases: results from large prospective cohorts and Mendelian Randomization analysis

Blood Cancer J. 2024 Mar 18;14(1):48. doi: 10.1038/s41408-024-01035-5.

Authors

Yang Li^#^{1

2}, Jia Chen^#^{1

2}, Ting Sun^#^{1

2}, Yunfei Chen^{1

2}, Rongfeng Fu^{1

2}, Xiaofan Liu^{1

2}, Feng Xue^{1

2}, Wei Liu^{1

2}, Mankai Ju^{1

2}, Xinyue Dai^{1

2}, Huan Dong^{1

2}, Huiyuan Li^{1

2}, Wentian Wang^{1

2}, Ying Chi^{1

2}, Lei Zhang^{3

4

5}

Affiliations

¹ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, 300020, China.
² Tianjin Institutes of Health Science, Tianjin, 301600, China.
³ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, 300020, China. zhanglei1@ihcams.ac.cn.
⁴ Tianjin Institutes of Health Science, Tianjin, 301600, China. zhanglei1@ihcams.ac.cn.
⁵ School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. zhanglei1@ihcams.ac.cn.

^# Contributed equally.

Abstract

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Hematologic Diseases* / genetics
Humans
Mendelian Randomization Analysis* / methods
Polymorphism, Single Nucleotide
Prospective Studies
Telomere
Telomere Homeostasis