In September 2022, deaths of pigs manifesting pox-like lesions caused by swinepox virus were reported in Tshuapa Province, Democratic Republic of the Congo. Two human mpox cases were found concurrently in the surrounding community. Specific diagnostics and robust sequencing are needed to characterize multiple poxviruses and prevent potential poxvirus transmission.
Keywords: Democratic Republic of the Congo; One Health; infectious diseases; monkeypox virus; mpox; orthopoxvirus; outbreak investigation; sexually transmitted infections; swinepox; swinepox virus; vector-borne infections; viruses; zoonoses.