We describe 10 patients with nonkeratitis Acanthamoeba infection who reported performing nasal rinsing before becoming ill. All were immunocompromised, 7 had chronic sinusitis, and many used tap water for nasal rinsing. Immunocompromised persons should be educated about safe nasal rinsing to prevent free-living ameba infections.
Keywords: Acanthamoeba; United States; amebae; granulomatous amebic encephalitis; nasal rinsing; parasites; tap water.