Pathogenesis, Prophylaxis, and Treatment of Candida auris

Biomedicines. 2024 Mar 1;12(3):561. doi: 10.3390/biomedicines12030561.

Abstract

Candida auris poses a serious threat to infection control and patient care since it can produce invasive infections that have a high fatality rate, has been linked to outbreaks in hospital environments, and is typically resistant to several antifungal medications. Since its first description in 2009, six clades have been described. The emerging fungal pathogen possesses adhesins that allow it to adhere to host tissues and medical devices, can form biofilms, produces various hydrolytic enzymes, employs several strategies to evade host immune responses, and exhibits high genetic diversity, which may contribute to its ability to adapt to different environmental conditions and evade host defenses. C. auris is very resistant to various disinfectants and may be difficult to detect.

Keywords: Candida auris; antifungal resistance; diagnosis; emerging threat; fungal pathogen.

Publication types

  • Review

Grants and funding

This work was supported by the Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, postdoctoral program contract number 28567/02.10.2023.