1 Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
2 St. Vincent's Healthcare Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Darlinghurst, New South Wales, Australia.
3 Department of Medicine and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri.
4 Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
5 Kinghorn Cancer Center, Darlinghurst, New South Wales, Australia.
Understandably, conventional therapeutic strategies have focused on controlling primary tumors. We ask whether the cost of such strategies is actually an increased likelihood of metastatic relapse.