Endocrine-metabolic assessment checklist for cancer patients treated with immunotherapy: A proposal by the Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE) and Italian Society of Pharmacology (SIF) multidisciplinary group

Maria Chiara Zatelli; Antongiulio Faggiano; Antonella Argentiero; Romano Danesi; Stella D'Oronzo; Stefano Fogli; Tindara Franchina; Francesco Giorgino; Nicola Marrano; Dario Giuffrida; Stefania Gori; Giampiero Marino; Rossella Mazzilli; Matteo Monami; Monica Montagnani; Lelio Morviducci; Annalisa Natalicchio; Alberto Ragni; Valerio Renzelli; Antonio Russo; Laura Sciacca; Enzo Tuveri; Gianluca Aimaretti; Angelo Avogaro; Riccardo Candido; Massimo Di Maio; Nicola Silvestris; Marco Gallo

doi:10.1016/j.ctrv.2024.102734

Endocrine-metabolic assessment checklist for cancer patients treated with immunotherapy: A proposal by the Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE) and Italian Society of Pharmacology (SIF) multidisciplinary group

Cancer Treat Rev. 2024 May:126:102734. doi: 10.1016/j.ctrv.2024.102734. Epub 2024 Apr 3.

Authors

Maria Chiara Zatelli¹, Antongiulio Faggiano², Antonella Argentiero³, Romano Danesi⁴, Stella D'Oronzo⁵, Stefano Fogli⁶, Tindara Franchina⁷, Francesco Giorgino⁸, Nicola Marrano⁹, Dario Giuffrida¹⁰, Stefania Gori¹¹, Giampiero Marino¹², Rossella Mazzilli¹³, Matteo Monami¹⁴, Monica Montagnani¹⁵, Lelio Morviducci¹⁶, Annalisa Natalicchio¹⁷, Alberto Ragni¹⁸, Valerio Renzelli¹⁹, Antonio Russo²⁰, Laura Sciacca²¹, Enzo Tuveri²², Gianluca Aimaretti²³, Angelo Avogaro²⁴, Riccardo Candido²⁵, Massimo Di Maio²⁶, Nicola Silvestris²⁷, Marco Gallo²⁸

Affiliations

¹ Section of Endocrinology, Geriatrics and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy. Electronic address: ztlmch@unife.it.
² Endocrinology Unit, Department of Clinical & Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy. Electronic address: antongiulio.faggiano@uniroma1.it.
³ Medical Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. Electronic address: argentieroantonella@gmail.com.
⁴ Oncology and Haematology Dept, University of Milano "La Statale", Milano, Italy. Electronic address: danesi.romano@gmail.com.
⁵ Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Bari, Italy. Electronic address: stella.doronzo@uniba.it.
⁶ Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address: stefano.fogli@unipi.it.
⁷ Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, Italy. Electronic address: tindara.franchina@unime.it.
⁸ Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy. Electronic address: francesco.giorgino@uniba.it.
⁹ Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy. Electronic address: nicola.marrano@uniba.it.
¹⁰ Department of Oncology, Istituto Oncologico del Mediterraneo, Viagrande, Catania, Italy. Electronic address: dgiuff57@gmail.com.
¹¹ Oncologia Medica, IRCCS Ospedale Don Calabria-Sacro Cuore di Negrar, Verona, Italy. Electronic address: stefania.gori@sacrocuore.it.
¹² Internal Medicine Department, Ospedale dei Castelli, Asl Roma 6, Ariccia, RM Italy. Electronic address: giampiero.marino@aslroma6.it.
¹³ Endocrinology Unit, Department of Clinical & Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy. Electronic address: rossella.mazzilli@gmail.com.
¹⁴ Diabetology, Careggi Hospital and University of Florence, Italy. Electronic address: matteo.monami@unifi.it.
¹⁵ Department of Precision and Regenerative Medicine and Ionian Area, Section of Pharmacology, University of Bari Aldo Moro, Bari, Italy. Electronic address: monica.montagnani@uniba.it.
¹⁶ Diabetology and Nutrition Unit, Department of Medical Specialties, ASL Roma 1 - S. Spirito Hospital, Rome, Italy. Electronic address: leliomorviducci@gmail.com.
¹⁷ Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy. Electronic address: annalisa.natalicchio@uniba.it.
¹⁸ Endocrinology and Metabolic Diseases Unit, Azienda Ospedaliero-Universitaria SS Antonio e Biagio e Cesare Arrigo of Alessandria, Alessandria, Italy. Electronic address: alberto.ragni@ospedale.al.it.
¹⁹ Diabetologist and Endocrinologist, Italian Association of Clinical Diabetologists, Rome, Italy. Electronic address: valerio.renzelli@gmail.com.
²⁰ Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy. Electronic address: antonio.russo@usa.net.
²¹ Department of Clinical and Experimental Medicine, Endocrinology Section, University of Catania Catania, Italy. Electronic address: laura.sciacca@unict.it.
²² Diabetology, Endocrinology and Metabolic Diseases Service, ASL-Sulcis, Italy. Electronic address: enzo.tuveri@gmail.com.
²³ Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy. Electronic address: gianluca.aimaretti@med.uniupo.it.
²⁴ Department of Medicine, Section of Diabetes and Metabolic Diseases, University of Padova, Padova, Italy. Electronic address: angelo.avogaro@unipd.it.
²⁵ Department of Medical Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy. Electronic address: riccardo.candido@yahoo.it.
²⁶ Department of Oncology, University of Turin, Turin, Italy. Electronic address: massimo.dimaio@unito.it.
²⁷ Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, Italy. Electronic address: nicola.silvestris@unime.it.
²⁸ Endocrinology and Metabolic Diseases Unit, Azienda Ospedaliero-Universitaria SS Antonio e Biagio e Cesare Arrigo of Alessandria, Alessandria, Italy. Electronic address: marco.gallo@ospedale.al.it.

PMID: 38604051
DOI: 10.1016/j.ctrv.2024.102734

Abstract

Immunotherapy with immune checkpoint inhibitors (ICI) is increasingly employed in oncology. National and international endocrine and oncologic scientific societies have provided guidelines for the management of endocrine immune-related adverse events. However, guidelines recommendations differ according to the specific filed, particularly pertaining to recommendations for the timing of endocrine testing. In this position paper, a panel of experts of the Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), and Italian Society of Pharmacology (SIF) offers a critical multidisciplinary consensus for a clear, simple, useful, and easily applicable endocrine-metabolic assessment checklist for cancer patients on immunotherapy.

Keywords: Consensus; Endocrine immune-related adverse events; Immune checkpoint inhibitors; Immunotherapy.

Publication types

Review

MeSH terms

Checklist
Endocrine System Diseases / chemically induced
Humans
Immune Checkpoint Inhibitors / therapeutic use
Immunotherapy* / methods
Italy
Medical Oncology / methods
Neoplasms* / drug therapy
Neoplasms* / immunology
Neoplasms* / therapy
Societies, Medical / standards

Substances

Immune Checkpoint Inhibitors