Discovery of new triterpene glycosides from Dendrobium officinale with their α-glucosidase and α-amylase inhibitory activity

Abstract

In this study, seven new pentacyclic triterpene glycosides, named dendrocinaosides A-G (1-7), and six known ones (8-13) were isolated from the whole plants of Dendrobium officinale. Their structures were determined by analyses of HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1-4, 8, and 9 potentially inhibited α-glucosidase and α-amylase activities with the IC₅₀ values ranging from 31.3 ± 2.2 to 42.4 ± 2.5 μM for anti α-glucosidase and from 36.5 ± 1.8 to 56.4 ± 2.0 μM for anti α-amylase activities, respectively, which were lower than that of the positive control, acarbose, showing IC₅₀ values of 47.1 ± 1.4 μM for anti α-glucosidase and 145.7 ± 2.2 μM for anti α-amylase.