No abstract available
Plain language summary
This JAMA Insights reviews the origin of APOL1 high-risk genetic variants, defines APOL1-mediated kidney disease, and discusses recommendations for screening and management.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Africa South of the Sahara / epidemiology
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Animals
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Apolipoprotein L1* / genetics
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Black People / genetics
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Black People / statistics & numerical data
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Black or African American* / genetics
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Black or African American* / statistics & numerical data
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Caribbean Region / epidemiology
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Central America / epidemiology
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Gene Frequency / genetics
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Genetic Testing
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Humans
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Kidney Diseases / diagnosis
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Kidney Diseases / epidemiology
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Kidney Diseases / ethnology
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Kidney Diseases / genetics
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Mice
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Renal Insufficiency, Chronic* / diagnosis
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Renal Insufficiency, Chronic* / epidemiology
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Renal Insufficiency, Chronic* / ethnology
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Renal Insufficiency, Chronic* / genetics
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South America / epidemiology
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Trypanosomiasis, African* / epidemiology
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Trypanosomiasis, African* / ethnology
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Trypanosomiasis, African* / genetics
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United States / epidemiology
Substances
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APOL1 protein, human
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Apolipoprotein L1