More than meets the eye: A conserved sensorimotor reflex helps unravel the circuit mechanisms of ASD

Romana J Hyde; Stephanie Rudolph

doi:10.1016/j.neuron.2024.04.003

More than meets the eye: A conserved sensorimotor reflex helps unravel the circuit mechanisms of ASD

Neuron. 2024 May 1;112(9):1375-1378. doi: 10.1016/j.neuron.2024.04.003.

Authors

Romana J Hyde¹, Stephanie Rudolph²

Affiliations

¹ Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.
² Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: stephanie.rudolph@einsteinmed.edu.

PMID: 38697019
DOI: 10.1016/j.neuron.2024.04.003

Abstract

Animal models are instrumental to understanding the mechanisms underlying autism spectrum disorder, yet translating human behavioral phenotypes remains challenging. Wang et al. leverage a conserved sensorimotor reflex to elucidate synaptic deficits in Scn2a haploinsufficiency and pilot novel rescue strategies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autism Spectrum Disorder* / genetics
Autism Spectrum Disorder* / physiopathology
Disease Models, Animal
Humans
Reflex / physiology