Concomitant osimertinib and antituberculosis therapy in an elderly patient with EGFR-mutated lung cancer and pulmonary tuberculosis: A case report

Thorac Cancer. 2024 Jun;15(17):1390-1394. doi: 10.1111/1759-7714.15324. Epub 2024 May 2.

Abstract

The concurrent incidence of lung cancer and tuberculosis is expected to escalate due to the projected growth in the older population. Combination therapy with osimertinib and antituberculosis drugs has not been well-established. We report a case of successful treatment involving the concomitant administration of osimertinib and antituberculosis drugs in an older patient, an 89-year-old female, diagnosed with epidermal growth factor receptor (EGFR)-mutant lung cancer and pulmonary tuberculosis. Accumulating evidence is warranted to develop an optimal treatment strategy for patients with lung cancer and tuberculosis.

Keywords: EGFR‐mutated lung cancer; case report; osimertinib; pulmonary tuberculosis; rifampicin.

Publication types

  • Case Reports

MeSH terms

  • Acrylamides* / therapeutic use
  • Aged, 80 and over
  • Aniline Compounds* / pharmacology
  • Aniline Compounds* / therapeutic use
  • Antitubercular Agents* / therapeutic use
  • ErbB Receptors* / genetics
  • Female
  • Humans
  • Indoles
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / pathology
  • Mutation*
  • Pyrimidines
  • Tuberculosis, Pulmonary* / drug therapy

Substances

  • osimertinib
  • Acrylamides
  • Aniline Compounds
  • ErbB Receptors
  • EGFR protein, human
  • Antitubercular Agents
  • Indoles
  • Pyrimidines