Maribavir for treatment of cytomegalovirus infection in a liver-transplanted patient

Ugeskr Laeger. 2024 Apr 8;186(15):V11230726. doi: 10.61409/V11230726.
[Article in Danish]

Abstract

Cytomegalovirus infection (CMV) can be fatal for organ transplant recipients as shown in this case report. Maribavir is a recently approved drug, which can be used for therapy-refractory CMV infection or when other treatment options cannot be used. The patient in this case report was a CMV-infected liver transplant recipient, who developed a severe erythema and high CMV DNA during valganciclovir therapy. Toxic epidermal necrolysis was suspected. The patient was treated with maribavir, and both CMV DNA and the skin normalised. This case illustrates that maribavir is a useful alternative to other antiviral drugs for CMV infection.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antiviral Agents* / therapeutic use
  • Benzimidazoles / adverse effects
  • Benzimidazoles / therapeutic use
  • Cytomegalovirus / drug effects
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections* / drug therapy
  • Dichlororibofuranosylbenzimidazole / analogs & derivatives*
  • Humans
  • Liver Transplantation* / adverse effects
  • Male
  • Middle Aged
  • Ribonucleosides* / administration & dosage
  • Ribonucleosides* / therapeutic use

Substances

  • Antiviral Agents
  • maribavir
  • Ribonucleosides
  • Benzimidazoles
  • Dichlororibofuranosylbenzimidazole