NT-proBNP point-of-care testing for predicting mortality in end-stage renal disease: A survival analysis

Chun Chen; Yin-Chen Hsu; Kuang-Wei Chou; Kuo-Song Chang; Ya-Hui Hsu; Wei-Huai Chiu; Chun-Wei Lee; Po-Sheng Yang; Wen-Han Chang; Yao-Kuang Huang; Pang-Yen Chen; Chien-Wei Chen; Yu-Jang Su

doi:10.1016/j.heliyon.2024.e30581

NT-proBNP point-of-care testing for predicting mortality in end-stage renal disease: A survival analysis

Heliyon. 2024 May 3;10(9):e30581. doi: 10.1016/j.heliyon.2024.e30581. eCollection 2024 May 15.

Authors

Chun Chen¹, Yin-Chen Hsu^{2

3}, Kuang-Wei Chou^{1

4}, Kuo-Song Chang^{1

5}, Ya-Hui Hsu¹, Wei-Huai Chiu⁶, Chun-Wei Lee^{5

7

8

9}, Po-Sheng Yang^{7

10}, Wen-Han Chang^{1

4

7

11

12

13}, Yao-Kuang Huang^{3

14

15}, Pang-Yen Chen^{1

4

5}, Chien-Wei Chen^{2

3

4}, Yu-Jang Su^{1

4

5

7

16}

Affiliations

¹ Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
² Department of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan.
³ Chang Gung University, College of Medicine, Taoyuan, Taiwan.
⁴ Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan.
⁵ Mackay Junior College of Medicine Nursing and Management, Taipei, Taiwan.
⁶ Graduate Institute of Automation and Control, National Taiwan University of Science and Technology, Taipei, Taiwan.
⁷ Department of Medicine, MacKay Medical College, New Taipei, Taiwan.
⁸ Cardiovascular Division, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
⁹ Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan.
¹⁰ Department of general surgery, MacKay Memorial Hospital, Taipei, Taiwan.
¹¹ Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan.
¹² Institute of Mechatronic Engineering, National Taipei University of Technology, Taipei, Taiwan.
¹³ School of Medicine, Taipei Medical University, Taipei, Taiwan.
¹⁴ Division of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan.
¹⁵ Division of Thoracic and Cardiovascular Surgery, Chia Yi Hospital, Ministry of Health and Welfare, Chiayi, Taiwan.
¹⁶ Division of Toxicology, Mackay Memorial Hospital, Taipei, 10449, Taiwan.

Abstract

This study examines the predictive value of elevated N-terminal-pro brain natriuretic peptide (NT-pro BNP) levels for mortality among patients with end-stage renal disease (ESRD). Data from 768 ESRD patients, excluding those with cancer or lost follow-up, were analyzed using Kaplan-Meier curves and Cox proportional hazards models over three years. Results indicated that patients with very high NT-pro BNP levels had shorter average survival times and a significantly higher risk of mortality (hazard ratio 1.43). Advanced age, ICU admission, and comorbidities like cerebrovascular diseases and chronic obstructive pulmonary disease also contributed to increased mortality risks. Thus, elevated NT-pro BNP is an independent risk factor for mortality in ESRD patients.

Keywords: ESRD; End-stage renal disease; N-Terminal-pro brain natriuretic peptide; NT-Pro BNP; Survival analysis.