CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications

Sci Rep. 2024 May 15;14(1):11120. doi: 10.1038/s41598-024-60997-5.

Abstract

Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. This paper presents an in depth exploration of the focusing achievable at the current CLEAR (CERN Linear Electron Accelerator for Research) facility, for beam energies >200 MeV. A shorter, more optimal quadrupole setup was also investigated using the TOPAS code in Monte Carlo simulations, with dimensions and beam parameters more appropriate to a clinical situation. This work provides insight into how a focused VHEE radiotherapy beam delivery system might be achieved.

MeSH terms

  • Electrons*
  • Humans
  • Monte Carlo Method*
  • Particle Accelerators / instrumentation
  • Radiotherapy / methods
  • Radiotherapy Dosage*
  • Radiotherapy Planning, Computer-Assisted / methods
  • Radiotherapy, High-Energy / instrumentation
  • Radiotherapy, High-Energy / methods