Purpose: The case of a 47-year-old female patient who underwent sigmoidectomy for metastatic colorectal cancer is reported. Treatment with capecitabine and 5-fluorouracil induced severe hypertriglyceridemia repeatedly.
Methods: Based on laboratory tests and clinical evaluations, treatment was suggested by specialists.
Findings: After treatment with capecitabine, the patient's triglycerides increased from 19.7 mmol/L to 42 mmol/L. It was proposed that the patient had multifactorial chylomicronemia syndrome triggered by secondary factors. Statins, fenofibrate, ezetimib, and metformin were added to the therapy. After metastases appeared, FOLFIRI (leucovorin calcium [folinic acid], 5-fluorouracil, and irinotecan hydrochloride) chemotherapy and biological treatment (cetuximab) followed and triglycerides increased to 55.3 mmol/L.
Implications: Monitoring triglyceride levels before and during therapy is suggested.
Keywords: 5-fluorouracil; Capecitabine; Hypertriglyceridemia; Metastatic colorectal cancer; Obesity; Type 2 diabetes mellitus.
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