Antidiabetic and antiulcer activity of methanolic extract of Tradescantia spathacea in rats

Pak J Pharm Sci. 2024 Mar;37(2):315-320.

Abstract

The present study was designed to assess Tradescantia spathacea's antidiabetic ability, as well as the antiulcer activity of the entire plant extract. The diabetic condition was evaluated using Streptozotocin's oral glucose tolerance test, diabetes-alloxan and diabetes-models. Antiulcer activities were observed in rats where gastric ulcers were either caused by oral administration of ethanol, or pyloric ligation. Standards include ranitidine, glibenclamide and sucralfate. In all models, the blood glucose levels of animals treated with the test extract were found to be significantly lower compared to diabetic care. Similarly, in all models, the ulcer index in the animals treated with the test extract was found to be significantly lower relative to the animals under vehicle supervision. Our findings say T. Spathacea extract has essential anti-diabetic properties, as well as antiulcer properties.

MeSH terms

  • Animals
  • Anti-Ulcer Agents* / isolation & purification
  • Anti-Ulcer Agents* / pharmacology
  • Blood Glucose* / drug effects
  • Blood Glucose* / metabolism
  • Diabetes Mellitus, Experimental* / drug therapy
  • Glucose Tolerance Test
  • Hypoglycemic Agents* / isolation & purification
  • Hypoglycemic Agents* / pharmacology
  • Male
  • Methanol / chemistry
  • Phytotherapy
  • Plant Extracts* / isolation & purification
  • Plant Extracts* / pharmacology
  • Rats
  • Rats, Wistar*
  • Solvents / chemistry
  • Stomach Ulcer* / chemically induced
  • Stomach Ulcer* / drug therapy
  • Stomach Ulcer* / pathology
  • Stomach Ulcer* / prevention & control