Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

Jatin P Shah; Helena Levyn; Cristina Valero; Dauren Adilbay; Alana Eagan; Junting Zheng; Mithat Gonen; Marc Cohen; Snehal Patel; Ian Ganly; Prathamesh Pai; Paolo Castelnuovo; Fang Ju Gao; Cesare Piazza; Piero Nicolai; Ben Panizza; James Bowman; Catherine Barnett; Luiz P Kowalski; Ronaldo Toledo; Dan M Fliss; John DeAlmeida; Ian Witterick; Philippe Herman; Walter Fontanella; Gregorio Sanchez Aniceto; Sefik Hosal; Serdar Ozer; Subramania Iyer; Richard Harvey; C Rene Leemans; Jan-Jaap Hendrickx; Marcelo Figari; Luis Boccalatte; Ken Ichi Nibu; Peter Clarke; Catherine Rennie; Zhu Yi Ming; Claudio Cernea; Sergio Goncalves; Rodney Schlosser; Fernando Dias; Zoukaa Sargi; Shahzada Ahmed; Wojciech Golusinski; Se Heon Kim; Shirley Y Su; Shaan M Raza; Franco DeMonte; Ehab Hanna

doi:10.1002/hed.27746

Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

Head Neck. 2024 Nov;46(11):2762-2775. doi: 10.1002/hed.27746. Epub 2024 May 21.

Authors

Jatin P Shah¹, Helena Levyn¹, Cristina Valero¹, Dauren Adilbay¹, Alana Eagan¹, Junting Zheng², Mithat Gonen², Marc Cohen¹, Snehal Patel¹, Ian Ganly¹, Prathamesh Pai³, Paolo Castelnuovo⁴, Fang Ju Gao⁵, Cesare Piazza⁶, Piero Nicolai⁶, Ben Panizza⁷, James Bowman⁷, Catherine Barnett⁷, Luiz P Kowalski^{8

9}, Ronaldo Toledo⁸, Dan M Fliss¹⁰, John DeAlmeida¹¹, Ian Witterick¹¹, Philippe Herman¹², Walter Fontanella¹³, Gregorio Sanchez Aniceto¹⁴, Sefik Hosal¹⁵, Serdar Ozer¹⁵, Subramania Iyer¹⁶, Richard Harvey¹⁷, C Rene Leemans¹⁸, Jan-Jaap Hendrickx¹⁸, Marcelo Figari¹⁹, Luis Boccalatte¹⁹, Ken Ichi Nibu²⁰, Peter Clarke²¹, Catherine Rennie²¹, Zhu Yi Ming²², Claudio Cernea⁹, Sergio Goncalves⁹, Rodney Schlosser²³, Fernando Dias²⁴, Zoukaa Sargi²⁵, Shahzada Ahmed²⁶, Wojciech Golusinski²⁷, Se Heon Kim²⁸, Shirley Y Su²⁹, Shaan M Raza³⁰, Franco DeMonte³⁰, Ehab Hanna²⁹

Affiliations

¹ Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
² Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
³ Head and Neck Surgical Oncology, Tata Memorial Hospital, Mumbai, India.
⁴ Department of Otorhinolaryngology, University of Insubria, Varese, Italy.
⁵ Department of Head and Neck Surgery, Beijing Tongren Hospital, Beijing, China.
⁶ Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Spedali Civili BS Piazzale Spedali Civili, Brescia, Italy.
⁷ Department of Head & Neck Oncology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
⁸ Head and Neck Reference Center, AC Camargo, Sao Paulo, Brazil.
⁹ Head and Neck Service, ICESP, São Paulo, Brazil.
¹⁰ University of Nicosia Medical School, Cyprus.
¹¹ Department of Otolaryngology - Head & Neck Surgery, University Health Network, Toronto, Ontario, Canada.
¹² ENT Department - Skull Base Center, Hispital Lariboisiere APHP, Paris, France.
¹³ Unit of Otorhinolaryngology - Maxillofacial, and Thyroid Surgery, University of Milan, Milan, Italy.
¹⁴ Oral and Maxillofacial Department, 12 de Octubre University Hospital, Madrid, Spain.
¹⁵ Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Atılım University, Medicana International Ankara, Ankara, Turkey.
¹⁶ Department of Head and Neck Surgery and Oncology, Amrita Institute of Medical Sciences, Kochi, India.
¹⁷ Sydney Ear Nose Throat Clinic, Darlinghurst, New South Wales, Australia.
¹⁸ Otolaryngology-Head and Neck Surgery, Amsterdam University Medical Center, VU University, Amsterdam, The Netherlands.
¹⁹ Head and Neck Surgery, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
²⁰ Department of Otolaryngology - Head & Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
²¹ ENT Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom.
²² Head and Neck Surgery, Beijing Cancer Center, Beijing, China.
²³ Department of Otolaryngology - Head & Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
²⁴ Department of Head and Neck Surgery, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
²⁵ Department of Otolaryngology, University of Miami, Miami, Florida, USA.
²⁶ Department of Otolaryngology - Head and Neck Surgery, University of Birmingham, University Hospitals Birmingham, Birmingham, United Kingdom.
²⁷ Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznan, Poland.
²⁸ Department of ENT, Yonsei University Health System, Seoul, South Korea.
²⁹ Department of Head and Neck Surgery, MD Anderson Cancer Center, Houston, Texas, USA.
³⁰ Department of Neurosurgery, MD Anderson Cancer Center, Houston, Texas, USA.

PMID: 38770972
PMCID: PMC11473241 (available on 2025-11-01)
DOI: 10.1002/hed.27746

Abstract

Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.

Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.

Results: The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.

Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

Keywords: global collaboration; multimodality treatment; prognostic factors; skull base tumors; survival outcomes.

Publication types

Multicenter Study

MeSH terms

Adult
Aged
Endoscopy
Female
Humans
International Cooperation
Male
Middle Aged
Neurosurgical Procedures / methods
Prognosis
Retrospective Studies
Skull Base Neoplasms* / mortality
Skull Base Neoplasms* / pathology
Skull Base Neoplasms* / surgery
Treatment Outcome

Abstract

Publication types

MeSH terms

Grants and funding